K-562 cell line


K-562 cell line is a human erythromyeloblastoid leukemia cell line, which was originally derived from the bone marrow of a patient with chronic myeloid leukemia. K-562 cells are widely used in research to study the mechanisms of leukemogenesis, cell differentiation, and drug discovery for various hematological malignancies.

K-562 cells are characterized by their ability to differentiate into various hematopoietic lineages, including erythroid and megakaryocytic cells, in response to various differentiation agents. They are widely used in the study of hematopoietic cell biology, signaling pathways, and cellular responses to various stimuli, including cytokines and chemotherapeutic agents.

K-562 cells are also used as a model system to screen potential therapeutic agents for various hematological malignancies, including leukemia, lymphoma, and myeloma. Researchers use K-562 cells to investigate the molecular mechanisms underlying drug resistance and to identify novel targets for therapeutic intervention.

It is important to handle and culture K-562 cells using appropriate techniques and conditions to ensure their optimal growth and viability. These include maintaining the cells in suitable culture medium, providing the appropriate temperature and humidity, and regularly monitoring cell confluence and viability.