MOLM-13 cell line is a human acute myeloid leukemia (AML) cell line that was established from the bone marrow of a patient with AML. MOLM-13 cells are widely used in research to study the mechanisms of leukemogenesis, cell differentiation, and drug discovery for AML and other hematological malignancies.

MOLM-13 cells are characterized by their ability to differentiate into myelomonocytic cells and are used as a model system to study the molecular mechanisms underlying AML pathogenesis, including genetic and epigenetic alterations. They are also used to investigate the mechanisms of drug resistance and to identify novel targets for therapeutic intervention.

MOLM-13 cells are commonly used in drug discovery and screening assays, as they are responsive to a wide range of chemotherapeutic agents, including targeted therapies such as tyrosine kinase inhibitors. Researchers use MOLM-13 cells to evaluate the efficacy and toxicity of potential therapeutic agents and to investigate the molecular mechanisms underlying drug resistance.

It is important to handle and culture MOLM-13 cells using appropriate techniques and conditions to ensure their optimal growth and viability. These include maintaining the cells in suitable culture medium, providing the appropriate temperature and humidity, and regularly monitoring cell confluence and viability.