A20 cell line is a murine (mouse-derived) B lymphocyte cell line that is often used in immunological research. This cell line was originally derived from a spontaneously arising tumor in a BALB/c mouse. A20 cells are known for their ability to produce immunoglobulins, specifically IgG2a and IgG2b.

A20 cells are widely used in the study of B cell biology, immune responses, and signaling pathways. Researchers also utilize A20 cells to investigate molecular mechanisms involved in cancer, inflammation, and autoimmune diseases, as well as to screen potential therapeutic agents for these conditions.

Since the A20 cell line is of mouse origin, it serves as an excellent in vitro model system for studying murine B cell biology and can be used in conjunction with in vivo mouse models to generate comprehensive data on the immune system and B cell-related pathologies.

It is important to note that A20 cells are a specific cell line and should not be confused with the A20 protein (also known as TNFAIP3), a ubiquitin-editing enzyme involved in regulating immune and inflammatory responses.